![]() ![]() In addition, c-Cbl is constitutively phosphorylated in LMP2A-expressing LCLs ( Engels et al., 2001). ![]() These interactions suggest that c-Cbl may interact with LMP2A-associated proteins with functional consequences. Cbl proteins preferentially interact with and target Src-family PTKs including Lyn, Fyn and Lck for degradation ( Andoniou et al., 2000 Kaabeche et al., 2004 Rao et al., 2002 Sanjay et al., 2001). Syk is a target of Cbl-mediated ubiquitination and degradation upon BCR stimulation ( Rao et al., 2001). Two Nedd4-family E3s, Nedd4 and AIP4/Itch, bind to three Cbl-family proteins and target them for degradation, which inhibits Cbl-mediated desensitization of activated EGFR and non-receptor c-Src PTKs ( Courbard et al., 2002 Magnifico et al., 2003). Several previous studies have shown that c-Cbl interacts with known LMP2A-associated proteins. The phosphorylation of Cbl proteins following signal stimulation is essential for the pivotal role of Cbl proteins for their adaptor function ( Swaminathan and Tsygankov, 2006). ![]() Cbl proteins are multivalent adapter proteins capable of interacting with multiple signal components ( Swaminathan and Tsygankov, 2006). These targets include Src-family and Syk PTKs ( Swaminathan and Tsygankov, 2006). c-Cbl is a RING-finger E3 that negatively regulates the BCR and other signal pathways by targeting multiple signal molecules for degradation. The proto-oncogenic protein c-Cbl and other Cbl-family proteins have been recognized as key players in the negative regulation of antigen receptor and other signaling pathways ( Swaminathan and Tsygankov, 2006). The phosphorylation of B cell signal molecules is critical for their recruitment to the plasma membrane and the formation of BCR signalosome. LMP2A ubiquitin-dependent processes are likely important for LMP2A function in EBV latent infection such as the modulation of LMP2A-induced signals which alter normal B cell development ( Casola et al., 2004 Ikeda et al., 2004).īCR stimulation triggers the activation of PTKs, which leads to the phosphorylation of numerous signal molecules such as adapter, docking and effecter proteins ( Kurosaki, 2002). In addition, LMP2A ubiquitination negatively regulates LMP2A signal transduction in B cell development ( Ikeda et al., 2003 Ikeda et al., 2004). In contrast to the BCR, LMP2A contains two PY motifs (PPXY) that specifically associate with Nedd4-family ubiquitin-protein ligases (E3s) resulting in the downmodulation of LMP2A activity by ubiquitinating both LMP2A and LMP2A-associated PTKs ( Ikeda et al., 2000 Ikeda et al., 2001 Winberg et al., 2000). The LMP2A amino-terminal domain interacts and activates with the Src family protein tyrosine kinase (PTK) Lyn and the Syk PTK ( Fruehling and Longnecker, 1997 Fruehling et al., 1998 Rovedo and Longnecker, 2008) in a constitutive manner mimicking a BCR providing development and survival signals in the absence of corresponding antigens ( Caldwell et al., 1998). The elucidation of differences between the BCR and LMP2A signaling may aide the development of novel therapeutic agents to treat EBV latent infections and EBV-associated cancers. The understanding of the molecular basis of LMP2A-mediated signaling is essential to clarify the involvement of LMP2A in EBV latent infections and EBV-related malignancies. LMP2A functions as a signalosome by constitutively associating and activating proteins normally associated with the B cell receptor (BCR) ( Longnecker, 2000). Latent membrane protein 2A (LMP2A) is an Epstein-Barr virus (EBV) encoded protein that has been implicated in regulating viral latency and pathogenesis in EBV infections ( Ikeda et al., 2005 Longnecker, 2000).
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You can make a temporary collage on a table, piece of paper or card, or even a plastic tray. If you don't have paper on a roll, you can just stick two sheets ofpaper together, like this. Now, our journey follows a long line, so you're going to need a long sheet of paper. Our journey is going to follow a trip from the city into the countryside. There's lots of different ways of showing a journey. If you're going to stick down your collage, you're going to need some glue, but if not, you'll need a camera so you can take a pictureof what you've made. Lots of different little bits of fabric and some cotton wool. Natural materials like sand, soil and some leaves. Some crepe paper and tissue paper, coloured card in lots of different colours, feathers, sandpaper.We've got some acetate here. But first, let's takea look at what you'll need. In this video, we're going to use collage Stuck in traffic? Queue’s taking too long? The Canva app will keep you productive.Hello. 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Public groups: No limit to the amount of public groups that can be created.Share citations in invite-only public groups. Share documents and citations in private groups. Private groups or public invite-only groups: Users can only create 1 private group OR invite-only public group with 3 group members.What kind of collaboration features does it offer? Grab citations from databases with the Zotero icon.After you have installed the web importer bookmarklet on your web browser, you can save citation information for major databases (Works with major web browsers).Zotero comes with some of the most popular citation styles (APA, MLA, Chicago) and additional styles can be downloaded from the Zotero Style Repository.Ĭan I save citations while I browse databases? Instructions on editing a citation style can be found here. ![]() Additional styles can be installed from within the desktop client. Mendeley comes with some of the most popular citation styles (APA, MLA, Chicago) and additional styles can be loaded. How many citation styles does it support?īoth Mendeley and Zotero use Citation Style Language, which offers over 7,000 free CSL citation styles. Information for installing free Word (Mac & Windows) and LibreOffice Plugins for Zotero for Firefox version.The free plugin for Word and LibreOffice is included in the Zotero Standalone version.Once you have downloaded Mendeley, you can install the plugins from within the program.There are free plugins for Word, LibreOffice, and BibTeX.However, once you sync your account with Zotero’s servers, the cloud storage limitations will activate.ĭoes it create in-text citations, footnotes, and bibliographies? By not syncing your Zotero account, you can maintain a library of citations and documents on ONE computer without having to use Zotero’s cloud storage.However, 2GB should provide you with significant space for your collection. You have to use Mendeley’s cloud storage in order to have a fully functioning account.Charges for adding additional storage space. ![]()
![]() Put on cap, screwing the band firmly tight. Pour into clean KERR Jars to within 1/2 inch of top of jar. To each cup of the fruit pulp and juice, add 1/4 cup of sugar and 1 teaspoon lemon juice. Press through colander, then through fine sieve. Combine 4 cups of fruit with 4 cups of water and heat slowly to simmering. Process in water bath for 20 minutes at simmering temperature. ![]() To prevent discoloration during storage, 1/2 teaspoon crystalline ascorbic acid (or 5 tablets of 50 milligrams) may be added to each quart of juice. Wash the grapefruit, cut in half and extract the juice. ![]() The entire procedure from extraction of the juice to processing must be carried on without delay. After extraction, the juice must not be allowed to stand exposed to the air. These will affect the color and flavor of the canned juice. This will help to keep rag, cell tissue and oil out of the juice. Ream the juice from the fruit by using a cone shaped juice extractor. 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This golden classic, trendy and will probably be evergreen for years to come. Our recommendation is to put a small amount of styling product on it and comb it all in one direction. This effect will be maintained no matter how little time you actually spend styling the rest up. This low maintenance hairstyle relies on keeping a well-trimmed skin fade by visiting the barber around once a week (depending on how fast your hair grows).Īs long as that graphic detail is kept neatly trimmed, the rest of your haircut will look sleek and elaborate. So, use a minimal touch of hands dipped in a light hold product (like a bit of styling foam), frizz it all up carelessly, and you’re good to go. To avoid looking like an actual member of a 90s boys band, it’s actually recommended to style your hair as little as possible after getting the required coloring and cut. The Frosted Tips look from the 90s is making a comeback, but with a definitive modern touch. The style will take care of itself as long as you visit the barber every couple of weeks for a refresh of the neatly trimmed aspect. The Stylish Afro FadeĪfro hair can be notoriously tricky to style unless you want to go for the bushy natural look or for the permanent dreadlocks.įor a third option, which is still low-maintenance enough, go for a short-trimmed look like this one. This will give you a rugged and relaxed look. To avoid time-wasting styling, keep the long part loosely tied in a sloppy looking man bun. Rugged Top Bun with Undercutįor an even cooler look, grow out only the top of your hair and keep the rest neatly trimmed with an undercut. To avoid a negligent look though, keep your beard groomed with a bit of beard oil (tips from our previous guide here), and your hair freshly washed. If you also grow out your beard as well, you can double up on both the charm and the saved time. Or visiting the barber for frequent cuts. Keeping your hair a bit longer than the usual short cut can win you bonus points in the time department.Īs long as you pick a relaxed and careless style, you won’t need to invest too much time styling it. These haircuts will require little to no grooming, as long as you visit the barber often enough to maintain their shape. There’s no need to spend tiresome minutes arranging your locks carefully before you leave the house, only to have everything come down anyway in a couple of hours. Stop worrying about hair products, having a stylish and up to date look was never about hair gel.įret no more: with the help of the experts from MenHairStylist, we’ve come up with a selection of the best low-maintenance haircuts for men. You’re going to leave the barbershop in 30 minutes looking like a proper dapper fellow and will continue to look the same all throughout the day. Men all around the world have a problem which can usually be fixed with a little pomade.īut what do you do when you’re in a hurry, it rains or you just want to wear a hat?Įasy, you show your barber one of these low-maintenance haircuts from down below. However, you won’t be charged any more money for this to happen, so it’s a win-win for both of us! And if you click any of those affiliate links, I’ll earn a commission (A.K.A. An honest disclosure: Just an F.Y.I., there are maybe be affiliate links in this post. It’s open-source and has a massive following, which is always a plus when it comes to any software. However, SketchUp does sit a little bit between TinkerCAD and Fusion36o in terms of advanced features, so if you find TinkerCAD to be limiting but need something a little more robust, SketchUp is worth trying out.īlender is probably the most advanced, fully-free 3D design software out there. In all honesty, if I had a choice between TinkerCAD and SketchUp, I’d go with TinkerCAD every single time.
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